ADAMTS1 and myocardial infarction: A Disintegrin and Metalloproteinase with Thrombospondin Motifs 1 (ADAMTS1) is a multifunctional extracellular protease that is highly conserved across mammalian species (>89% amino acid identity between human and mouse).[6] It has emerged as a critical player in cardiac repair and remodeling following MI.