Five years after EOT, follow-up of 60 patients showed that their HBV DNA levels decreased over time, with 8/12 HBeAg+ patients showing HBeAg seroconversion, and 55/60 patients had reduced serum HBV DNA levels, with 45/60 becoming HBV DNA negative in their serum and 40 patients had normalized ALT levels, and no patients developed HCC or cirrhosis [5, 25]. The gene discussed is GPT; the disease is hepatocellular carcinoma.