CRP and major depressive disorder: Meanwhile, another study found that CRP was associated with reduced functional connectivity in a widely distributed network including the ventral striatum, parahippocampal gyrus/amygdala, orbitofrontal and insular cortices, and the posterior cingulate cortex in MDD patients, and these broad alterations were centralized in the vmPFC, representing a hub for the effects of inflammation on network function in the whole brain (Yin et al. 2019).