Moreover, the gray matter functional correlates of CRP in MDD were spatially correlated with functional gene categories involving inflammatory signaling pathways (macrophage activation, NF‐κB signaling, and JUN kinase activity), specific neurotransmitters (serotonin, GABA, and glutamate), and diverse behavioral domains (sensorimotor, cognition, emotion, and sleep). The gene discussed is MAPK9; the disease is major depressive disorder.