Second, the gray matter functional correlates of CRP in MDD were spatially correlated with functional gene categories involving inflammatory signaling pathways (macrophage activation, NF‐κB signaling, and JUN kinase activity), specific neurotransmitters (serotonin, GABA, and glutamate), and diverse behavioral domains (sensorimotor, cognition, emotion, and sleep). This evidence concerns the gene MAPK9 and major depressive disorder.