CRP and major depressive disorder: For instance, a study reported that increased CRP was associated with decreased functional connectivity between the ventral striatum and the ventromedial prefrontal cortex (vmPFC), which in turn correlated with increased anhedonia in MDD patients, and increased CRP predicted decreased dorsal striatal to vmPFC and presupplementary motor area connectivity, which correlated with decreased motor speed and increased psychomotor slowing (Felger et al. 2016).