ICAM‐1 is expressed by the vascular endothelium, monocytes/macrophages, and lymphocytes and is demonstrated to be increased in both, healthy older adults and patients with pathological diseases, including hypertension, diabetes, and atherosclerosis (Dougherty et al. 1988; Van der Meer et al. 2002). The gene discussed is ICAM1; the disease is atherosclerosis.