Alanine aminotransferase (ALT) and gamma‐glutamyl transferase (GGT) demonstrated strongly positive genetic correlations with HCV‐negative HCC (rg = 0.42, p = 2.50 × 10−4; rg = 0.36, p = 1.09 × 10−4, respectively). This evidence concerns the gene GPT and hepatocellular carcinoma.