The baseline data of the training cohort revealed significant differences in LAA, hypertension (EH), T2DM, NIHSS score, age, Lipoprotein(a), Apolipoprotein B, neutrophils, lymphocyte, and Lp-PLA2 between the recurrence and non-recurrence groups (P < 0.05, Table 1), indicating that these variables were sensitive indicators for PIS. This evidence concerns the gene APOB and Hypertension.