Consistently, the number of cleaved caspase-1-positive MM cells from VK*myc mice was significantly increased after U18666A treatment (Figures S8C-D), and U18666A treatment also increased the production of HMGB1, IL-18, and IL-1β in the bone marrow (Fig. 6N). The gene discussed is CASP1; the disease is Miyoshi myopathy.