Different studies have been conducted on genes coding for inflammatory cytokines whose modifications could genetically predispose to the development of sepsis:: IL-1α (-889 T/C), IL-1β (-511 C/T, + 3962 T /C), IL-1 RA (1100 T/C), IL-4 RA (+ 1902 G/A), IL-4 (-1098 T/G, -590 T/C, -33 T/C), IL-6 (-174 C/G, -560 G/A), IL-10 (-1082 A/G, -819 C/T, -592 C/A), IL-12 (-1188 C/A), γIFN (+ 874 A/T), TGF-β1 (codon 10 C/T, codon 25 G/C), TNF-α (-308 G/A, -238 G/A) and IL-2 (-330 T/G, + 166 G/T) [16]. The gene discussed is TNF; the disease is rheumatoid arthritis.