MAPT and dementia: In two separate studies (N = 78; Age 23–84 years) [117], and Chongqing Ageing & Dementia Study (CADS) cohort (N = 87; Age: 40 years and over) [118], CSF sPDGFRβ was significantly higher in AD and correlated with CSF albumin (a marker of BBB integrity), total tau, and phosphorylated tau (markers of neuronal injury).