MAPT and Alzheimer disease: Previous cohort studies (N = 607; Age: 65.99 ± 8.79 years; ChiCTR2100049131) [24], the AD Neuroimaging Initiative (ADNI; N = 509), and Parkinson’s Progression Markers Initiative (PPMI; N = 302) [35] also identified strong negative associations between CP volume and CSF proteins (Aβ, p-tau, and t-tau) in patients with MCI and AD dementia.