CHI3L1 and Alzheimer disease: In a clinical study, Korean AD (N = 61, Age: 74.55 ± 1.56 years) and MCI (N = 49, Age: 68 ± 1.00 years) patients were evaluated for plasma CHI3L1 levels in blood using ELISA, and higher concentrations were found in AD than in the HC or MCI patients, and no significant variation in moderate/severe AD [50].