In two separate studies (N = 78; Age 23–84 years) [117], and Chongqing Ageing & Dementia Study (CADS) cohort (N = 87; Age: 40 years and over) [118], CSF sPDGFRβ was significantly higher in AD and correlated with CSF albumin (a marker of BBB integrity), total tau, and phosphorylated tau (markers of neuronal injury). This evidence concerns the gene MAPT and Alzheimer disease.