APP and Alzheimer disease: These include alterations in the hippocampus [19, 120] and cortex [17] of 5xFAD mice, the cortex of APP-KI mice [17], the cortex of 3xTg mice [24], the hippocampus of APP/PS1 mice [21, 22], the brains of ArcAβ mice [16], and the hippocampus and cortex of an STZ-induced rat model of AD [15].