Lack of increased LATS1/2 phosphorylation in the 7-month-old 5xFAD mouse hippocampus [19] contrasts with the previous finding of increased LATS1/2 phosphorylation in the 3-month-old 5xFAD mouse cortex [17], suggesting potential regional and temporal differences in Hippo-related dysfunction in AD. This evidence concerns the gene LATS1 and Alzheimer disease.