Notably, Hippo activation is associated with cognitive deficits and neuronal loss, as HDAC3 knockdown in the APP/PS1 hippocampus both reverses pathological activation of Hippo signaling and protects against cognitive deficits and neuronal loss [22], implying an upstream role for HDAC3 in Hippo pathway regulation, though whether the cognitive improvements directly resulted from inactivation of Hippo signaling was not fully explored in the study. The gene discussed is HDAC3; the disease is Cognitive impairment.