Complementary time-lapse studies in human iPSC-derived neurons carrying the APP KM670/671NL mutation and AD mice provide further evidence of the pathological sequence of events with intracellular Aβ sequestering YAP in the cytoplasm, leading to decreased YAP-TEAD transcriptional activity, and subsequent ER ballooning and cell death [17]. Here, APP is linked to Alzheimer disease.