LATS1 and Alzheimer disease: Hypo-Hippo signaling was noted in C. elegans models of AD with global or neuronal overexpression of mammalian Aβ42, where reduced phosphorylation of MST1 and LATS1/2 homologs cst-1 and wts-1 led to enhanced nuclear translocation of unphosphorylated YAP via interaction with Mint3 homolog lin-10 [25].