Inhibition of Hippo kinases, while beneficial for boosting YAP activity and neuronal survival in AD models, may carry a risk of promoting tumorigenic processes, particularly as Hippo signaling crosstalks with other tumor suppressor pathways including p53 [258], PI3K-Akt-mTOR [227, 259, 260], and Wnt [228–230, 261]. The gene discussed is TP53; the disease is Alzheimer disease.