O-GlcNAcylation of YAP at S109 in HEK293T and pancreatic cancer L3.6 cells [64] and at T241 in liver cancer cell lines [65] in response to high extracellular glucose enhances YAP activity and stability by disrupting its interaction with LATS1 and β-TrCP E3 ubiquitin ligase. The gene discussed is YAP1; the disease is familial pancreatic carcinoma.