While YAP protein expression appears to be minimal in neurons of the neocortex and spinal cord during both development and adulthood [105, 106], neuron-specific YAPdeltaC isoforms and FL-YAP have been detected in neurons under pathological insult, such as in the spinal cord of transgenic ALS mice [10]. Here, YAP1 is linked to amyotrophic lateral sclerosis.