MST1 inhibition or depletion protects against neurodegeneration in multiple rodent models of neurodegenerative conditions, including ALS, where MST1 knockout reduced neurodegeneration [111]; CUMS-induced depression, where MST1 knockdown rescued increased p38 activation in response to chronic stress and protected against stress-induced depression-like behaviors, impairment of synaptic plasticity [112], and altered neural oscillation patterns [235]; and traumatic brain injury (TBI), where administration of CGP3466B protected against neuronal apoptosis by inhibiting MST1 via PCMT1 [236]. Here, MST1 is linked to amyotrophic lateral sclerosis.