APP and Alzheimer disease: Reduced YAP levels are also observed in astrocytes within the hippocampus of APP/PS1 mice, where they promote premature astrocytic senescence through decreased CDK6 expression [21], which can lead to increased secretion of inflammatory cytokines [138] and other senescence-associated secretory phenotype (SASP) factors that disturb surrounding cells and exacerbate AD pathology [139].