Third, while YAP-TEAD transcriptional activation forms the canonical output of Hippo signaling, YAP can also bind to non-TEAD transcription factors and induce alternate transcription programs [44, 265, 266]; thus, characterizing transcriptional activation in response to AD-related alterations in YAP levels and YAP subcellular localization could help to further elucidate the mechanisms of YAP-driven cell death or survival. Here, YAP1 is linked to Alzheimer disease.