Adrenocorticotropic hormone (ACTH) stimulation was performed given concern for secondary adrenal insufficiency after abrupt discontinuation of decades-long glucocorticoid dosing; however, cortisol was appropriately stimulated, reaching 32.3 ug/dL (891.16 nmol/L; RR 5–23 ug/dL; 137.95-634.57 nmol/L) 30 min after ACTH administration—baseline 11.4 ug/dL (314.53 nmol/L). Here, POMC is linked to Adrenal insufficiency.