The entorhinal cortex, basal forebrain and locus coeruleus are some of the earliest regions to exhibit tau pathology [2], along with emerging evidence for the sensitivity of hypothalamic WPNs to tau [65], signifying the importance of neuronal, circuitry and regional vulnerabilities to proteinopathy and failed proteostasis for understanding and treating AD. The gene discussed is MAPT; the disease is Alzheimer disease.