PHF1 and Alzheimer disease: Sakakibara et al. demonstrated no AT8 + tau in the LC of AppNL−G−F mice [66], indicating the importance of the human tau knock-in in AppNL−G−FxMAPT mice for modelling Aβ-tau-autophagy effects, as we demonstrate significant and progressive LC tau pathology at PHF1 and CP13 epitopes, and the validity to AD patients [65].