Notably, the BBB-permeable angiotensin converting enzyme (ACE) inhibitor, captopril, or the angiotensin-receptor blocker (ARB), telmisartan, have shown efficacy in counteracting this microglia-mediated synaptic pruning, reversing the DNRab-induced memory impairment (Nestor et al. 2018; Carroll et al. 2024). This evidence concerns the gene ACE and memory impairment.