VAMP2 and Behcet disease: Additionally, lithium treatment has been shown to significantly reduce aberrant VAMP2-positive puncta along neuronal processes in cells transfected with the DISC1 breakpoint mutant (Lee et al. 2011)—a gene strongly implicated in BD (Carter 2007; Macgregor et al. 2004; Maeda et al. 2006; Perlis et al. 2008).