Toluidine blue staining results showed that compared with the control group, the number of Nissl bodies in the hippocampus of mice in T2DM and Pg groups was significantly decreased (P < 0.001), and the number of Nissl bodies in the Pg + T2DM group was further reduced compared with the T2DM group (P < 0.001, Fig. 3B and C). The gene discussed is JUP; the disease is type 2 diabetes mellitus.