The expressions of microglia-neuron interaction genes BDNF (Fig. 5F), NGF (Fig. 5G), DAP12 (Fig. 5H), CX3CR1 (Fig. 5I) and CX3CL1 (Fig. 5J) showed that the expression of BDNF in the T2DM group was significantly decreased (P < 0.05), and Pg had no significant regulatory effect on BDNF in the control group (P > 0.05, Fig. 5F). Here, CX3CR1 is linked to type 2 diabetes mellitus.