In addition, the expressions of neuroinflammatory factors in brain tissue of T2DM mice were significantly increased, hippocampal microglia were activated, the expressions of BDNF and NGF were decreased, the expressions of DAP12, CX3CR1, and CX3CL1 were increased, and Pg further promoted the inflammatory response of hippocampal microglia in T2DM mice. Here, JUP is linked to type 2 diabetes mellitus.