The expression of neuroinflammatory factors in brain tissue was examined by RT-PCR, and it was found that the expressions of IL-1β, iNOS, and COX2 in brain tissue of T2DM mice were significantly increased (P < 0.05), and the expression of inflammatory factors in brain tissue of Pg + T2DM group was further increased compared with that of T2DM/Pg group (P < 0.05, Fig. 5A-C). This evidence concerns the gene JUP and type 2 diabetes mellitus.