PRKAA1 acts as an energy sensor in ATP-deprived conditions, linking the AMPK–mTOR pathway to metabolic adaptation under hypoxia; enriched in “cellular response to calcium ion” (GO:0071277), “protein phosphorylation” (GO:0006468), “negative regulation of TORC1 signaling” (GO:1904262), and “Hypertrophic cardiomyopathy” (oas05410) [55]. This evidence concerns the gene CRTC1 and hypertrophic cardiomyopathy.