CD4 and peripheral T-cell lymphoma, not otherwise specified: RNA seq of CD4+, CD8+, and CD4−CD8− peripheral T-cell lymphomas (PCTL) showed that while CD4+ tumors had a consistent gene expression profile that included upregulation of GATA3 and PI3K/AKT/mTOR signaling and downregulation of PTEN, CD8+ and CD4−CD8− tumors were more heterogeneous [76].