As shown in Figure 7, the transcript and protein levels of IFN-α, IFN-β, RIG-I, MDA5, MAVS, TRAF3, TBK1, and IRF3 in the PRRSV-infected cell group by anti-FcγRI IgG pre-treatment were significantly declined at 12 h and 24 h post-infection compared to those in the PRRSV-infected cell group by RNI pre-treatment (Figure 7a–p,r). This evidence concerns the gene IRF3 and infection.