Therefore, blocking this axis activates the STING pathway, restores phagocytosis in macrophages and DCs, promotes antigen cross presentation, and enhances recruitment of cytotoxic immune cells (i.e., CD8+ T cells), reprogramming the TME and converting the HCC tumor into a hot phenotype that works synergistically with ICIs, chemotherapies, and radiotherapies [123,127]. The gene discussed is CD8A; the disease is hepatocellular carcinoma.