CASP12 and neurodegenerative disease: It is expressed in various organs including the eyes and brain [49,50], and many studies have shown that caspase-12 participates in neural cell death [34,37,51,52,53,54,55,56,57,58,59] and contributes to many neuronal diseases including neurodegenerative diseases [57,58] and brain ischemic injury [37,59], as well as retinal diseases [53,54,55].