For instance, caspase-12 was shown to inhibit mucosal immunity to bacterial infection via suppression of the Nod-Rip2-NF-kB signaling pathway [33], as well as via inhibition of caspase-1 activation and subsequent IL-1β and IL-18 secretion [28], although the latter remains controversial [29]. The gene discussed is CASP1; the disease is bacterial infectious disease.