As shown in Figure 3, key molecules participating in apoptosis (caspase-3 and caspase-8) and necroptosis (RIP3 and MLKL) were activated in infected mice compared to age-matched, uninfected controls, indicating that both apoptosis and necroptosis participate in retinal degeneration during MCMV latency. Here, CASP3 is linked to retinal degeneration.