During treatment with orally administered GS-441524, unexpected observations, such as lymphocytosis, eosinophilia [4,17,18], elevation in liver enzyme activity, e.g., alanine aminotransferase (ALT) and alkaline phosphatase (ALP) [4,17], and/or an increase in symmetric dimethylarginine (SDMA) [2,4,9] have been reported in some cats. The gene discussed is GPT; the disease is Increased total eosinophil count.