In severe relative to mild COVID-19 patient BALF, we observed downregulation of all eIF2B isoforms (eIF2B1-5; Figure 3A) and an upregulation of GADD34, ATF4, and CHOP, all indicative of increases in p-eIF2⍺, suggesting that severe COVID-19 patient BALF cells are likely in a translationally repressed state, driven by eIF2⍺ phosphorylation. Here, PPP1R15A is linked to COVID-19.