Unlike other tests for type II diabetes and PD, in this study, we used the Morris water maze test to verify the improvement of short-term memory, long-term memory, and spatial probing in AD rats, followed by the measurement of various biochemical parameters, including acetylcholinesterase (AchE) in rat cortices; Aβ40, β-secretase (BACE1), and 8-hydroxy-2′-deoxyguanosine (8-oxodG) in rat hippocampi; dopamine in rat brain striata; and SOD, CAT, GSH-Px, and MDA in rat cortices and livers, for the elucidation of the possible mechanisms involved in AD progression. The gene discussed is ACHE; the disease is Alzheimer disease.