Examples include disulfide linkers, which are cleaved through thiol exchange; hydrazone linkers, which degrade in acidic environments; and peptide linkers, which are hydrolyzed by lysosomal proteases such as cathepsin B. While cleavable linkers enhance specificity and payload delivery to tumor cells, they pose the risk of premature cleavage in the bloodstream [23,25]. This evidence concerns the gene CTSB and neoplasm.