PCNA and neoplasm: Preclinical studies have shown that NaDCA salts are associated with a reduction in tumor cell proliferation rate and metastatic spread, and activation of apoptosis [22]; NaDCA inhibits U87 MG and PBT24 glioblastoma xenografts growth, frequency of tumor invasion, and the number of blood vessels in the chicken chorioallantoic membrane model; NaDCA impacts on tumor proliferating cell nuclear antigen (PCNA) and enhancer of zest homolog 2 (EZH2) expression in the tumor tissue cells [24].