It was reported that by regulating SLC12A5 expression, EZH2 activates the WNK1-OSR1-NKCC1 (lysine-deficient protein kinase-1—oxidative stress responsive 1—NKCC1) pathway to promote glioma migration and tumor invasion, while also promoting SLC12A5 DNA methylation [58]. This evidence concerns the gene EZH2 and central nervous system cancer.