NUCLEOLIN and glioblastoma: Other aptamer–siRNA chimeras could be illustrated by the following: (a) AS1411–siRNA Nanoconjugates (discussed in Table 4); (b) the bi-specific aptamer based on AS1411 targeting NCL and a “CpG” oligodeoxynucleotide targeting Toll-like receptor TLR9 that was designed to deliver siRNA specific to osteopontin mRNA, which is highly expressed in GBM [10,107]; (c) AS1411 aptamer conjugated with SMG1 RNAi, which has proved to be an efficient and well-tolerated enhancer of immune response against various tumors, including CNS ones [108].