SNCA and synucleinopathy: DNA aptamer F5R1 binds to fibrillary alpha-synuclein αSyn and was encapsulated in rabies virus glycoprotein-coated exosomes; after intraperitoneal administration in a murine model of synucleinopathy, this F5R1-exosome conjugate avoided passing through the BBB because it was retrogradely transported by trans-synaptic transmission through peripheral neurons towards central nervous system, where it diminished αSyn aggregation in the substantia nigra and also motor disturbances in mice [20,26].