Anti-EpCAM (epithelial cell adhesion molecule) or anti-VEGF aptamers coated with polyamidoamine and conjugated with mesoporous silica nanoparticles proved potent anti-angiogenic effects due to inhibition of in vivo and in vitro EGFR expression and increased the tumor-targeted efficiency of the encapsulated CRISPR and Cas9 plasmid therapy that is regarded as “magic scissors” [82,94,95]. The gene discussed is EGFR; the disease is neoplasm.