INS and diabetes mellitus: These included immune-related signaling pathways (e.g., “CD4+ T-Cell Function Decline in HIV”, “Natural Killer Cell Activation”, and “IL2 Expression Targets”) and insulin-related networks (e.g., “Natural Killer T-Cell Roles in Diabetes Mellitus Type 1”, “Insulin activation of MEF/MYOD Expression Targets”, and “IGF1 activation of ELK/SRF/HIF1A/MYC/SREBF Expression Targets”) (Table 3).