In summary, our data reveal an unrecognized Meth-induced neuronal necroptosis via RIPK1–RIPK3-mediated MLKL translocation to the mitochondrial membrane (Figure 6), which may provide novel insights into the mechanism of Meth-induced neuronal death, and targeting MLKL could thus be considered as a promising strategy for intervention in Meth-induced neurodegenerative diseases. This evidence concerns the gene RIPK3 and neurodegenerative disease.