Furthermore, Wilkinson and colleagues [145] demonstrated that murine and humanized antibodies used as an anti-idiotypic vaccine were examined in mice transgenic for human MUC1—a membrane bound, polymorphic epithelial mucin expressed at the luminal surface of glandular epithelium highly expressed in an underglycosylated form on carcinomas and metastatic lesions—which were challenged by murine epithelial tumor cells transfected with human MUC1 and showed impaired tumor growth at day 35. The gene discussed is MUC1; the disease is carcinoma.