Moreover, although we have reported that CD11b+ Gr-1+ splenocytes isolated on day 7 post-infection possess the ability to suppress dendritic cell maturation and CD4+ T cell proliferation [31], and CD11b+ Gr-1+ cells that increase in peripheral blood at 48 h post-immunization include cells that home to the spleen (Supplementary Figure S2), not all the cells may exhibit the same behavior as the splenic cells previously assessed [31]. This evidence concerns the gene CD4 and infection.