As shown in Supplementary Table S5, the limited presentation capacity of HLA-A*02:05 in tumor cells may reflect its low predicted affinity (NetMHCpan %Rank = 3.946) and complex stability (NetMHCstabpan %Rank = 4.00), which could impact endogenous peptide presentation efficiency despite exogenous rescue. The gene discussed is HLA-A; the disease is neoplasm.