INS and type 2 diabetes mellitus: The pathways relevant to T2DM, and enriched by our subset of common targets, were predicted to include metabolic pathways, insulin resistance, lipid and atherosclerosis, adherens junction, phospholipase D signaling pathway, platelet activation, diabetic cardiomyopathy, focal adhesion, cGMP-PKG signaling pathway, AGE-RAGE (in diabetic complications) signaling pathway, HIF-1 signaling pathway, and regulation of lipolysis in adipocytes.