Other studies have revealed that ursolic acid, oleanolic acid, and other related pentacyclic triterpenes can improve DM by activating the insulin signaling pathway [159,160,161] and increasing insulin sensitivity via the IRS/PI3K/AKT signaling pathways in 3T3-L1 adipocytes [162,163,164,165]. This evidence concerns the gene PIK3CG and diabetes mellitus.