The six top-ranked compounds (i.e., quercetin, luteolin, ursolic acid, isoquercitrin, 2α-hydroxy-ursolic acid, and oleanolic acid) predicted in the CT network to be involved in the antidiabetic activity of M. officinalis were docked with eight hub targets relevant to T2DM (i.e., AKT1, PIK3R1, INSR, EGFR, RELA (NF-kB p65 subunit), GSK3B, PTP1B, and PPARα). This evidence concerns the gene PIK3R1 and type 2 diabetes mellitus.