These included metabolic pathways, insulin resistance, lipid and atherosclerosis, adherens junction, phospholipase D signaling pathway, platelet activation, diabetic cardiomyopathy, focal adhesion, cGMP-PKG signaling pathway, AGE-RAGE (in diabetic complications) signaling pathway, HIF-1 signaling pathway, and regulation of lipolysis in adipocytes (Figure 6). The gene discussed is AGER; the disease is diabetic cardiomyopathy.