The enriched hub targets in the TP network included proteins previously reported for their potential involvement in the pathogenesis of T2DM, such as PIK3R1 [72,73], INSR [74], RELA [75,76], GSK3B [77,78], PIK3CG [79,80], and FYN [64,81], and two known target classes of existing antidiabetic compounds/drugs, PTP1N [49] and PPARγ/α [50,51]. This evidence concerns the gene PIK3R1 and type 2 diabetes mellitus.