ESR1 and type 2 diabetes mellitus: The top-10 ranking hub genes/T2DM targets (i.e., with degrees higher than twice the median degree of the entire network) were identified as EGFR, SRC, AKT1, TNF, ESR1, HDAC1, CYP3A4, PPARG, PARP1, and MMP9 (Figure 2 and Figure 3).