Another exclusive intestinal helminth infection is that caused by Syphacia muris. A previous infection with this nematode resulted in downregulation of caspase 3 and APC, and the upregulation of COX2, promoting epithelial cell proliferation and increasing aberrant crypt formation in a CRC model induced by 1,2-dimethylhydrazine (DMH). The gene discussed is APC; the disease is colorectal carcinoma.