Importantly, loss of function of an individual inflammasome gene did not prevent development of MAIDS in either NLRP3−/− mice, NLRP1b−/− mice, or AIM2−/− mice, as determined by the appearance in all animals of a prominent generalized lymphadenopathy characteristic of MAIDS by 10 weeks after retrovirus inoculation, as reported by us previously [32]. This evidence concerns the gene AIM2 and Lymphadenopathy.