Herein, we show that MAIDS mice deficient in either the NLRP3, NLRP1b, or AIM2 inflammasome share a pattern of atypical MCMV retinal disease that is similar, if not identical, to that observed in MCMV-infected MAIDS mice deficient in key components of the canonical pyroptosis pathway, i.e., caspase-1, GSDMD, or IL-18 [32]. Here, NLRP3 is linked to Abnormal retinal morphology.