CASP1 and Abnormal retinal morphology: Using the MAIDS model of MCMV retinal necrosis, we have shown previously that MCMV-infected eyes of mice with MAIDS produce significantly high amounts of caspase-1, GSDMD, IL-1β, and IL-18 transcripts, as well as translated protein products within the ocular compartment during the onset and development of retinal disease [31,32].