At the same time, this has brought new opportunities for the study of tumor microbes, e.g., after sequencing of fecal samples from different stages of CRCs and analyzing the sequencing of CRC tumors, it was found that some specific microbes may be present in tumors and their microenvironments [3,11,19], such as Fn enrichment in CRC [20,21]. Here, FN1 is linked to colorectal carcinoma.