Indeed, upon VDR binding, vitamin D significantly reduces the level of proinflammatory cytokines such as TNFα, IL-1β, IL-6, deeply involved in neuroinflammatory and pathogenetic mechanisms in PD, AD, or MS neurodegeneration, and protects neural tissues from damage through the increase in anti-inflammatory cytokine IL-10 [56,57]. Here, VDR is linked to Parkinson disease.