SIRT1 acts in a multidirectional manner on the cardiovascular system, exerting protective effects [49,121,122,123], including systemic hypertension, atherosclerosis, vascular complications of diabetes, heart failure, myocardial infarction, ischemia and reperfusion injury, cardiomyopathy, cardiotoxicity, coronary heart disease, aortic aneurysm, or deep vein thrombosis [43,46,49,50,79,124,125,126,127,128,129,130,131,132], which was very elegantly reviewed by Ding et al. [58]. The gene discussed is SIRT1; the disease is heart failure.