This dysregulation, along with the interplay of other pathways, such as bone morphogenetic protein (BMP) signaling and the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) pathway, plays a pivotal role in the pathological remodeling of the pulmonary vasculature and the progression of PAH. This evidence concerns the gene AKT1 and pulmonary arterial hypertension.