Specifically, scutellarein effectively reduced hypoxia-induced Akt1, proto-oncogene, non-receptor tyrosine kinase Src (SRC), epidermal growth factor receptor (EGFR), MMP9, and prostaglandin-endoperoxide synthase 2 (PTGS2) expression in human PAH PASMCs in a SIRT1-dependent manner [157]. This evidence concerns the gene SIRT1 and pulmonary arterial hypertension.