STAT3 and gastric cancer: Another study showed that the core mechanism of AA-PMe anti-gastric cancer lies in the inhibition of Signal Transducer and Activator of Transcription 3 (STAT3) signaling pathway, which blocks the tyrosine phosphorylation of STAT3 by inhibiting the activity of JAK2 kinase, down-regulates the expression of cyclin D1, c-Myc, and Bcl-2 expression and up-regulating the pro-apoptotic protein Bax, reducing the proliferation of gastric cancer cells and their mobility, and thus inducing apoptosis to achieve anti-tumor effects [103].