Functional studies demonstrated that inhibition of plectin significantly suppressed HCC proliferation, migration, invasion, cytoskeletal remodeling, and tumor growth via CRISPR/Cas9-mediated knockout, deletion of the intermediate filament-binding domain, or pharmacologic inhibition with plecstatin-1 (PST) in Huh7 and SNU-475 cells [26]. The gene discussed is PLEC; the disease is hepatocellular carcinoma.