Notably, the IL-17 signaling pathway (hsa04657), HIF-1 signaling pathway (hsa04066), and PD-L1 expression/PD-1 checkpoint pathway (hsa05235) were tightly linked, suggesting the concerted modulation of immune activation, inflammatory responses, and immune checkpoint signaling in the context of HIV infection. The gene discussed is HIF1A; the disease is HIV infectious disease.