Moreover, E. natalensis phytochemicals were significantly enriched in the HIV-1 infection pathway (hsa05170), with overlapping genes converging on PI3K–Akt–MTOR signaling, NFκβ activation, MAPK cascades, calcium signaling, Toll-like receptor signaling, TNF signaling, and apoptotic pathways. The gene discussed is NFKB1; the disease is HIV-1 infection.