Furthermore, the human immunodeficiency virus 1 (HIV-1) infection pathway (hsa05170) was significantly enriched with overlapping genes including PAK4, CHEK1, CHUK, MAPK14, PTK2B, MTOR, TBK1, NFκβ1, MAPK1, MAPK8, MAPK10, RAC1, RELA, APOBEC3G, CALM1, CALM3, CASP3, CASP9, CDK1, and CDC25C (Figure S3). The gene discussed is RAC1; the disease is HIV-1 infection.