In contrast, NLRP3 and IL-1β inhibition in mature mice led to a reduction in the asthma-like phenotype [82,83], suggesting that the NLRP3 inflammasome and its subsequent IL-1β signaling could either be beneficial or detrimental in RV-associated asthma development and exacerbation depending on the subject’s developmental status. This evidence concerns the gene NLRP3 and asthma.