Early clinical studies observed signs of inflammasome activation (caspase-1 activation, IL-1β and IL-18 secretion), as well as increased LDH release (a sign of lytic cell death) in the sera of severe COVID-19 patients, suggesting the potential involvement of pyroptosis in severe SARS-CoV-2 infection [89,90,91,92,93]. Here, IL1B is linked to COVID-19.