ACE2 and infection: Nakandakari-Higa et al. utilized the S82M/F83Y/H353K triple mutations of mACE2 to generate a minimally edited mouse model-Ace2, which is susceptible to multiple SARS-CoV-2 strains, including USA-WA1/2020 and B.1.1.529 (Omicron), benefiting research on the immune responses to sequential infection in mice [28].