Excessive ROS production by T15 treatment activates different counter mechanisms trying to partially protect the tumor cells against oxidative stress, such as the higher expression of NOX1 on MCF7 cells; PARK7, PRDX1 and PRDX3 on MDA-MB231 cells; and UCP1 elevation in PANC1 cells. This evidence concerns the gene PRDX3 and neoplasm.