IGF1 and sarcopenia: In aged mice, Withania somnifera extract increases muscle mass, prevents inflammation-associated muscular atrophy, modulates muscle protein turnover, and promotes mitochondrial biogenesis via the IGF-1/Akt/mTOR pathway [202], while in a mouse model of sarcopenia, steamed ginseng berry powder increases myotube diameter and decreases the mRNA levels of sarcopenia-associated markers [203].