BRAF and colorectal cancer: This phenomenon, known as microsatellite instability (MSI), has been strongly linked to the accumulation of mutations in oncogenic drivers such as KRAS, neuroblastoma RAS viral oncogene (NRAS), and v-Raf murine sarcoma viral oncogene homolog B1 (BRAF), ultimately contributing to colorectal cancer development [68,69,70].