Notable variants include those in CBR1 (Carbonyl reductase 1) and CBR3 (Carbonyl reductase 3), ABCC1 (ATP-binding cassette subfamily C member 1) and ABCC5 (ATP-binding cassette subfamily C member 5), related to ATP-binding cassette transporters, and SLC22A (solute carrier gene), which are predominantly implicated in pediatric populations and patients treated for acute lymphoblastic leukemia [6]. The gene discussed is CBR1; the disease is acute lymphoblastic leukemia.