Oral gavage at 25–100 mg/kg/day for one week attenuates myocardial ischemia–reperfusion injury in rats, possibly via suppressing the NF-κB pathway [91], while the in vitro anti-pyroptotic effect of amentoflavone was demonstrated in attenuating the doxorubicin-induced cardiotoxicity inhibition of the stimulator of interferon gene/nod-like receptor protein 3 signaling pathway, thereby validating its efficacy as a cardioprotective agent [92]. The gene discussed is NFKB1; the disease is myocardial ischemia.