Lastly, PIKfyve inhibition was shown to reduce both the trafficking of tau seeds into lysosomes and the induction of tau aggregation and to promote secretion of neurotoxic aggregates in Amyotrophic Lateral Sclerosis (ALS) patient iPSC-derived induced motor neurons, proposing a candidate strategy for the treatment of tauopathies [15,16]. The gene discussed is MAPT; the disease is amyotrophic lateral sclerosis.