IL1B and osteoarthritis: Research has found that SS-a can inhibit the release of inflammatory mediators NO and PGE2 in human osteoarthritis chondrocytes stimulated by IL-1β and can increase the reduction in MMP1 expression from 22.00% to 80.00%, MMP3 expression from 35.00% to 80.00%, and MMP13 expression from 30.77% to 84.62%, thereby exerting anti-inflammatory effects.