CD4 and Splenomegaly: In our conditions, the intraperitoneal infusion of CD4+CD25− cells to immunocompromised mice evoked only a moderate colitis over the 8 weeks of the investigation: a gradual worsening of the clinical status, characterized by a slow increase in DAI score and splenomegaly, was detected in comparison with sham mice, which received CD4+ cells in toto.